The first F-ring modified ciguatoxin analogue showing significant toxicity.
نویسندگان
چکیده
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent neurotoxic polycyclic ethers. We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.
منابع مشابه
First- and second-generation total synthesis of ciguatoxin CTX3C.
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 17 شماره
صفحات -
تاریخ انتشار 2010